Kobiza Latest Questions

Anonymous
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Mr AJ, a 75-year-old patient receiving warfarin to prevent DVT, comes to the clinic with an INR of 12, despite taking the same dose of the drug. There is no evidence of bleeding. He was previously well controlled on warfarin. ...Read more

Mr AJ, a 75-year-old patient receiving warfarin to prevent DVT, comes to the clinic with an INR of 12, despite taking the same dose of the drug. There is no evidence of bleeding. He was previously well controlled on warfarin. What should be done? 

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  1. 1. Blood components may be given during a transfusion to help stop your bleeding. Blood components are the parts of blood that help it to clot. Examples are: Plasma, clotting factors, and platelets.   2. Vitamin K may be given to decrease your INR and bleeding.

    1. Blood components may be given during a transfusion to help stop your bleeding. Blood components are the parts of blood that help it to clot. Examples are: Plasma, clotting factors, and platelets.   2. Vitamin K may be given to decrease your INR and bleeding.

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Anonymous
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Mrs BC, a 56-year-old woman on warfarin therapy for atrial fibrillation with mitral stenosis, appears to become resistant to warfarin after previously good control on 5 mg daily. Her INR does not rise above 1.4 even when her warfarin dose ...Read more

Mrs BC, a 56-year-old woman on warfarin therapy for atrial fibrillation with mitral stenosis, appears to become resistant to warfarin after previously good control on 5 mg daily. Her INR does not rise above 1.4 even when her warfarin dose is increased to 20 mg daily. What can be done to find the cause of the resistance? 

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  1. The most common cause of warfarin resistance is non-compliance. Others may include poor absorption, hypersensitivity to vitamin K, rapid drug deactivation, and high intake of vitamin K.

    The most common cause of warfarin resistance is non-compliance. Others may include poor absorption, hypersensitivity to vitamin K, rapid drug deactivation, and high intake of vitamin K.

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